About Lymphoma Non-Hodgkin

Non-Hodgkin lymphomas can occur at any age and are often marked by lymph nodes that are larger than normal, fever, and weight loss. There are many different types of non-Hodgkin lymphoma. These types can be divided into aggressive (fast-growing) and indolent (slow-growing) types, and they can be formed from either B-cells or T-cells. B-cell non-Hodgkin lymphomas include Burkitt lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell non-Hodgkin lymphomas include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma. Lymphomas that occur after bone marrow or stem cell transplantation are usually B-cell non-Hodgkin lymphomas. Prognosis and treatment depend on the stage and type of disease. 

Diffuse Large B-Cell Lymphoma

DLBCL is a cancer of B-lymphocytes in the lymphatic system.¹ Molecular, pathogenic, and clinical features distinguish 2 subtypes of DLBCL²:

• Germinal center B-cell–like DLBCL, originating in germinal center B cells, has a 60% 5-year survival rate²
• Activated B-cell–like DLBCL, originating in the post germinal center B cell, has a 35% 5-year survival rate²

DLBCL Demographic Statistics

• DLBCL accounts for about 1 of every 3 cases of non-Hodgkin’s lymphoma1
• DLBCL is usually aggressive, marked by rapidly growing tumors in lymph nodes, spleen, liver, bone marrow, or other organs⁵

DLBCL Epidemiology

• DLBCL occurs mostly in older people (average age is mid-60s).1 Immunocompromise (eg, due to HIV infection) is another risk factor¹
• The 5-year survival rate for DLBCL is 50.4%³

The symptoms of DLBCL include rapidly growing tumors in the lymph nodes, spleen, liver, bone marrow, or other organs.⁵ Other symptoms include fever, night sweats, and weight loss.⁵