About Lymphoma Non-Hodgkin
Non-Hodgkin lymphomas can occur at any age and are often marked by lymph nodes that are larger than normal, fever, and weight loss. There are many different types of non-Hodgkin lymphoma. These types can be divided into aggressive (fast-growing) and indolent (slow-growing) types, and they can be formed from either B-cells or T-cells. B-cell non-Hodgkin lymphomas include Burkitt lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell non-Hodgkin lymphomas include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma. Lymphomas that occur after bone marrow or stem cell transplantation are usually B-cell non-Hodgkin lymphomas. Prognosis and treatment depend on the stage and type of disease.
Diffuse Large B-Cell Lymphoma
DLBCL is a cancer of B-lymphocytes in the lymphatic system.1 Molecular, pathogenic, and clinical features distinguish 2 subtypes of DLBCL2:
- Germinal center B-cell–like DLBCL, originating in germinal center B cells, has a 60% 5-year survival rate2
- Activated B-cell–like DLBCL, originating in the post germinal center B cell, has a 35% 5-year survival rate2
DLBCL Demographic Statistics
- DLBCL accounts for about 1 of every 3 cases of non-Hodgkin’s lymphoma1
- DLBCL is usually aggressive, marked by rapidly growing tumors in lymph nodes, spleen, liver, bone marrow, or other organs5
- DLBCL occurs mostly in older people (average age is mid-60s).1 Immunocompromise (eg, due to HIV infection) is another risk factor1
- The 5-year survival rate for DLBCL is 50.4%3
The symptoms of DLBCL include rapidly growing tumors in the lymph nodes, spleen, liver, bone marrow, or other organs.5 Other symptoms include fever, night sweats, and weight loss.5
1. American Cancer Society. Non-Hodgkin lymphoma. www.cancer.org/acs/groups/cid/documents/webcontent/003126-pdf.pdf. Accessed April 14, 2011.
2. Lossos IS. Molecular pathogenesis of diffuse large B-cell lymphoma. J Clin Oncol. 2005;23:6351-6357. PMID: 16155019
3 .Clarke C, O’Malley C. Non-Hodgkin lymphoma. In SEER Survival Monograph. National Cancer Institute. www.seer.cancer.gov/publications/survival/surv_nonhodgkin.pdf. Accessed April 14, 2011.
4. US Department of Health and Human Services. National Cancer Institute. Sending the right signal. http://home.ccr.cancer.gov/inthejournals/staudt.asp. Accessed April, 22, 2011.
5. US Department of Health and Human Services. National Cancer Institute. What you need to know about™ non-Hodgkin lymphoma. NIH Publication No. 07-1567.